Weird and bad drug interactions are everywhere. Here’s one we didn’t hear about until recently: Combined use of SSRIs and NSAIDs increases the risk of gastrointestinal adverse effects. Here’s a meta-analysis from 2021.

We talked about Pennsylvania Lieutenant Governor John Fetterman, his amazing wife, and his awesome house in a previous links post; now he’s running for the Senate.

An interesting breakdown of Effective Altruism’s recent ill-fated $14 million introduction to politics and an attempt to describe what an actually effective, Realpolitik approach might look like.

It’s always weird to learn about new historical figures we happen to have caught on film: here’s an interview from 1927 with Sir Arthur Conan Doyle about writing Sherlock Holmes and having, in his words, “psychic experiences”.

bad news about cockroach sex — or as the twitter thread says, BUGS SUGAR SEX MAGIK

Bringing empiricism to new topics will be one of the signatures of the 21st century; here’s a great example of finding the perfect author photo with the clever application of photoshop and crowdsourcing. “It also might become my real-life look,” he says. “Because my lovely wife Cassandra said I looked hotter this way.”

More internet science from Troof on nootropics. Hopefully the first of many projects! 

Wikipedia is already well-known for being the repository of all human knowledge, but it still sometimes manages to surprise us. Consider for example the page, ​​Order of battle for the 2022 Russian invasion of Ukraine. If this is anything close to correct, maybe is Wikipedia now one pillar of the intelligence community?

We’ve wanted something like this for a while, and here it is: A list of ways AIs have learned to cheat at videogames. Bad news for attempts to align AI with human values but good news in that some of their strategies, while inventive, are not exactly Skynet. For example, consider: “Agent kills itself at the end of level 1 to avoid losing in level 2.”

Speaking of preparing for the cyberpunk future: comics about self managed abortion and sources of abortion pills, just in case.

In other future news, Futurama was right:

Love food but hate herbicides? How do you feel about LASERS

We’ve kind of been sleeping on Bartosz Ciechanowski but something like this is clearly the future of engineering textbooks. What is this guy’s day job? Should someone just hire him (and a small team?) to create open-source internet engineering manuals for the 21st century? 

Purple.com was “a single-page website created [by Jeff Abrahamson] in 1994. It consisted of no links or text and its only content was a purple background.” This was until November 2017, when it was sold to the internet mattress company, Purple, Inc. for around $900,000. So Jeff created ISoldPurple.com

Cannons: 

First-year recap on a startup that tries to do local/community news different. Kind of surprised they’re still focusing on an ad revenue model but we agree that local news is an undervalued area.

Guy tweets at Microsoft and asks them to release the source code for movie maker from 1995 and they said “okay here you go”